Решение:
\( \frac{4}{6} - \frac{1}{3} + \frac{1}{2} - \frac{1}{16} \)
\( = \frac{2}{3} - \frac{1}{3} + \frac{1}{2} - \frac{1}{16} \)
\( = \frac{1}{3} + \frac{1}{2} - \frac{1}{16} \)
\( = \frac{1 \cdot 2 + 1 \cdot 3}{6} - \frac{1}{16} \)
\( = \frac{2+3}{6} - \frac{1}{16} \)
\( = \frac{5}{6} - \frac{1}{16} \)
\( = \frac{5 \cdot 8 - 1 \cdot 3}{48} \)
\( = \frac{40 - 3}{48} = \frac{37}{48} \)
Ответ: \( \frac{37}{48} \).