Преобразуем смешанные числа в неправильные дроби:
\(3\frac{1}{4}=\frac{13}{4}\), \(2\frac{1}{6}=\frac{13}{6}\).
\[25.48\cdot\frac{13}{4}-\left(3.75-\frac{13}{6}\right):\frac{1}{6}\]
\(25.48\cdot\frac{13}{4}=82.81\),
\[3.75-\frac{13}{6}=\frac{15}{4}-\frac{13}{6}=\frac{45-26}{12}=\frac{19}{12}.\]
\[\frac{19}{12}:\frac{1}{6}=\frac{19}{12}\cdot6=\frac{19}{2}=9.5.\]
\[82.81-9.5=73.31.\]
Ответ: 73,31.