4⁻² × 8⁻⁶ / 2⁻²² = (2²)⁻² × (2³)⁻⁶ / 2⁻²² = 2⁻⁴ × 2⁻¹⁸ / 2⁻²² = 2⁻⁴⁻¹⁸ / 2⁻²² = 2⁻²² / 2⁻²² = 2⁻²²⁻⁽⁻²²⁾ = 2⁻²²⁺²² = 2⁰ = 1